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Chrüterei Stein Gruppe

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Malik Salleh
Malik Salleh

Sex With Mature Man

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Sex With Mature Man

Among patients with systemic lupus erythematosus (SLE), cancer risks overall were associated with older age at diagnosis and male sex, and lung cancer specifically was related to smoking, analysis of data from a large multicenter cohort found.

In a multivariable analysis, the hazard ratio for any type of cancer among patients enrolled in the Systemic Lupus International Collaborating Clinics Inception Cohort was 1.05 (95% CI 1.03-1.06) for greater age at baseline, while the risk for women was lower, with a hazard ratio of 0.47 (95% CI 0.26-0.85), reported Sasha Bernatsky, MD, of McGill University in Montreal, and colleagues.

As shown in their study online in Arthritis Care & Research, for lung cancer specifically a history of smoking more than 15 cigarettes per day was associated with an almost seven-fold increased risk (HR 6.64, 95% CI 1.43-30.9).

Interest has been growing with regard to the risk of cancer among patients with autoimmune diseases, including lupus, because of a potential role of inflammation in malignancy development. In addition, certain medications, such as cyclophosphamide, have been linked with cancer in the past.

To address this knowledge gap, the researchers analyzed data for 1,668 patients enrolled in the cohort from 1999 to 2011, who were seen yearly with information collected on disease activity, medication usage, and cancer diagnoses.

When the researchers compared the incident cancers according to baseline patient characteristics, the results showed that whereas 89.3% of patients without cancer were women, only 78.3% of those who developed cancer were.

Mean age at the time of SLE diagnosis was 34.2 in the no-cancer group compared with 45.6 in the cancer group. Current or past smoking was reported in 33.3% of the no-cancer group but in 47.7% of the cancer group. White race was reported for 48.7% of the no-cancer group vs 67.7% of the cancer group.

In an unadjusted univariate analysis, factors positively associated with any type of cancer were older age at SLE diagnosis (HR 1.06, 95% CI 1.04-1.07), white race (HR 2.24, 95% CI 1.33-3.78), and ever smoking (HR 1.72, 95% CI 1.06-2.80), while female sex was associated with a lower risk (HR 0.35, 95% CI 0.20-0.60). However, in the multivariate analysis, only older age and female sex remained significant.

The researchers then estimated risks for the specific types of cancer. For breast cancer, only older age at the time of diagnosis showed a significantly increased risk in the multivariate analysis (HR 1.06, 95% CI 1.02-1.10), while antimalarial use was associated with a lower risk (HR 0.28, 95% CI 0.09-0.90).

None of the lung cancer patients had been treated with cyclophosphamide or methotrexate, but all had received long-term treatment with antimalarials; it was not possible, therefore, to provide risk estimates for those medications, the team noted.

With hematologic cancers, once again older age at SLE diagnosis had a significant association (HR 1.06, 95% CI 1-1.13), as did having ever been in the highest quartile of SLE disease activity (HR 7.14, 95% CI 1.13-45.3). All patients with these malignancies were white and had ever smoked but none had been treated with cyclophosphamide, so risk estimates for those factors also could not be calculated.

The observation that male sex and older age at the time of SLE diagnosis were associated with higher risks in most types of cancer "may be, at least in part, because these demographic groups are at greater cancer risk in the general population," Bernatsky and colleagues wrote.

Aging brings life transitions that can create opportunities for older adults to redefine what sexuality and intimacy mean to them. Some older adults strive for both a sexual and intimate relationship, some are content with one without the other, and still others may choose to avoid these types of connections.

With age, impotence (also called erectile dysfunction, or ED) also becomes more common. ED is the loss of a


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